Endocrine Abstracts

Background: Maternal cortisol levels increase during pregnancy and prenatal cortisol exposure have been linked to cognitive function in childhood. Higher activity of the enzyme 11β-hydroxysteroid-dehydrogenase type 2 (11β-HSD2) downregulates the amount of maternal cortisol crossing the placenta by inactivation of cortisol to cortisone. In childhood, boys perform significantly poorer in tests of intelligence than girls.Aim: To investigate associ...

Background: Gender affirming hormonal treatment (GAHT) is for many a cornerstone of transgender care. National data regarding use of hormonal treatment by transgender persons are limited.Aim: To assess use of GAHT in transgender persons.Design: National register-based cohort study in Danish transgender persons followed from 2000 until 2018. The main outcome measure was redemption of GAHT. Persons with an ICD-10 diagnosis code of &#...

Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in...

Background: Higher testosterone levels during pregnancy in women with polycystic ovary syndrome (PCOS) could be associated with longer offspring ano-genital distance (AGD).Aims: To compare AGD between offspring of mothers with PCOS and controls and to determine possible associations between maternal 3rd trimester testosterone levels and offspring AGD at three months of age.Methods: The study was part of the prospective s...

Background: Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear.Purpose: To measure changes in body composition, pain perception, quality of life and adrenal function after TRT or placebo in opioid treated men with chronic non-malignant pain.Methods: Double-blinded, placebo-controlled study in 41 men (&#62...

Context: Acromegaly is a rare and insidious disease associated with severe somatic morbidity but data on socioeconomic status are scarce.Objective: To study the socioeconomic status in acromegaly in a population based, nationwide follow-up study.Patients and Methods: All incident cases of acromegaly (n = 576) during the period 1997–2010 were included, representing 10.116 years at risk. For every patient, 100 pers...

Introduction: We questioned the justification of general recommendations for assessment of hypopituitarism in patients with traumatic brain injury (TBI), and aimed to describe the prevalence of hypopituitarism in a national TBI population of patients admitted to a Danish hospital in 2008, as compared to healthy controls.Patients and methods: We included 463 patients (18–65 years) hospitalized ≥24 h, with more than subtle TBI as indicated by lo...

Objective: To investigate the effect of pioglitazone on cortisol metabolism in PCOS.Design: Thirty insulin resistant PCOS patients were randomized to either 16 weeks of pioglitazone (30 mg/day) or placebo treatment. Before and after intervention, patients underwent 24 h 20 min.-integrated blood sampling for measurement of cortisol and 24 h excretion of cortisol, cortisone and steroid metabolites (cortisol, corticosteron, androgen, and 17-hydroxyprogester...

Objective: Transgender persons often experience low socioeconomic status. Gender affirming treatment aims to improve gender dysphoria. We assessed employment rates in transgender persons compared to controls and demographic, health and treatment-related factors associated with unemployment in transgender persons.Methods: National register-based cohort study in Danish transgender persons with diagnosis code of gender identity disorder during year 2000-202...

Background: Although polycystic ovary syndrome (PCOS) constitutes a common endocrinopathy, there are several issues which confuse clinicians during everyday practice.Objective: To define the current status of knowledge of the full spectrum of PCOS among European endocrinologists.Methods: A detailed questionnaire comprising 41 items covering various aspects of diagnosis and management of women with PCOS was shared via web among memb...